Bunnie XO, wife of country musician Jelly Roll, disclosed that a weight-loss medication sent her into severe depression with suicidal thoughts. During her podcast “Dumb Blonde,” she revealed that she had taken retatrutide (reta), a Lilly drug in late-stage trials and not yet FDA-approved, which she obtained from a wellness center in Nashville. Within the first week, she felt sick; within two weeks, she looked and felt slimmer. In the fourth week, when she increased her dose by one unit, she experienced “mental numbness” followed by crisis: “I literally got sent into the worst suicidal depression that I’ve had since 2020. I didn’t think I was going to make it through the two weeks.”
The 45-year-old podcaster described emotional numbness where she could no longer find joy in music that normally brought her happiness. “You could see like my eyes were black. I just drove in silence because I just couldn’t handle anything. It was either overstimulating or it was to the point where it just stole my joy. I had no joy, like nothing to live for. It was so dark.” After stopping the drug for 20 days, her joy began “finally” returning. She acknowledged the limitations of her experience: “My story is not what’s going to happen to you. There’s so many people who are taking reta and love it and all that. But something happened with me.”
Lilly confirmed in a statement that retatrutide is “an investigational molecule that is legally available only to participants in Lilly’s clinical trials,” warning that “no one should consider taking anything claiming to be retatrutide outside of a Lilly-sponsored clinical trial” and cautioning about “fake medicines.” Fox News medical analyst Dr. Marc Siegel noted that retatrutide is a “triple agonist” targeting GLP-1, GIP, and glucagon receptors, and has “been linked potentially to depression and suicidal thoughts, as have the GLP-1 drugs, where some studies have shown increased psychiatric risks.” Mental health effects may stem from impacts on brain dopamine, serotonin, and norepinephrine levels, which affect mood and appetite. Any individual experiencing significant depressive or suicidal symptoms should seek immediate professional help.
This article is an AI-assisted summary. All facts and figures are drawn from the original report: https://www.foxnews.com/health/jelly-rolls-wife-says-weight-loss-drug-sent-her-worst-suicidal-depression